AndrewLeifer - Network

Also: there are two supplementary figures too. Here's 1.

Also: there are two supplementary figures too. Here's 1.

Congrats to authors Wayan Gauthey, Francesco Randi, Anuj Sharma and Sandeep Kumar!

Congrats to authors Wayan Gauthey, Francesco Randi, Anuj Sharma and Sandeep Kumar!

New single-figure paper out in Current Biology: Light evokes stereotyped global brain dynamics in C. elegans by first author Wayan Gauthey....

New single-figure paper out in Current Biology: Light evokes stereotyped global brain dynamics in C. elegans by first author Wayan Gauthey.

Immobilized worms exhibit stereotyped neural oscillations often called manifolds. We wondered: are they internally generated? Gauthey shows that bright light commonly used for imaging is sufficient to evoke the oscillations and that a known light-sensitive pathway contributes.

https://doi.org/10.1016/j.cub.2023.10.043

The worm is a uniquely powerful playground to understand the interplay between a neural network’s structure, transcriptome and function...

The worm is a uniquely powerful playground to understand the interplay between a neural network’s structure, transcriptome and function and we are excited to help contribute a new piece, signal propagation, to the puzzle.

Our measurements also provide an empirically grounded method of running simple simulations to predict the network’s response to arbitrary...

Our measurements also provide an empirically grounded method of running simple simulations to predict the network’s response to arbitrary stimulation, in this interactive web app here: https://funsim.princeton.edu

The signal propagation atlas itself is a resource for the C. elegans community to help make sense of individual circuits and behaviors. It...

The signal propagation atlas itself is a resource for the C. elegans community to help make sense of individual circuits and behaviors. It can also be browsed interactively online and compared to the connectome here: https://funconn.princeton.edu

The ability to compare wiring to signal propagation in the worm may help inform our understanding of new connectomes coming online in flies...

The ability to compare wiring to signal propagation in the worm may help inform our understanding of new connectomes coming online in flies and other organisms.

We found several instances of wireless signaling, including on fast timescales: peptides released extrasynaptically travel across the milieu...

We found several instances of wireless signaling, including on fast timescales: peptides released extrasynaptically travel across the milieu to bind other neurons. Extrasynaptic peptidergic signaling is not new, but we argue its role in neural dynamics may be underappreciated.

We find some interesting surprises. Eg. a connectome-constrained model of neural dynamics often poorly predicts our measured responses,...

We find some interesting surprises. Eg. a connectome-constrained model of neural dynamics often poorly predicts our measured responses, because: 1) the connectome is ill-suited to constrain all parameters needed for accurate prediction and 2) neurons also signal “wirelessly”, ie via dense core vesicle mediated extrasynaptic signaling.

Our signal propagation atlas of C. elegans is now out in Nature! We measure the network’s response to optogenetic stimulation of each...

Our signal propagation atlas of C. elegans is now out in Nature
! We measure the network’s response to optogenetic stimulation of each neuron in the head, one at a time-- over 23,000 neuron pairs. Congrats to Francesco Randi, Anuj Sharma, & Sophie Dvali! https://www.nature.com/articles/s41586-023-06683-4

Out @PLOSBiology! Inhibitory signals from turning neurons gate the worm's response to mechanosensory stimuli! Beautiful work by Sandeep...

Out @PLOSBiology! Inhibitory signals from turning neurons gate the worm's response to mechanosensory stimuli! Beautiful work by Sandeep Kumar and co-authors Anuj Sharma, Andrew Tran & Mochi Liu https://plos.io/455hWOh

Now out at @eLife! Kevin Chen and Rui Wu report a new method to study odor guided navigation of worms and fly larvae on agar. Metal oxide...

Now out at @eLife! Kevin Chen and Rui Wu report a new method to study odor guided navigation of worms and fly larvae on agar. Metal oxide sensors continuously characterize the odor landscape experienced by the animal. This was a fun collaboration with Marc Gershow of NYU Physics. Congrats team! https://doi.org/10.7554/eLife.85910