BugsInYourGuts - Network

This is great (disclaimer: I am a long-time DOME fan girl).More microbiome research needs to be grounded in microbial ecology and functional...

This is great (disclaimer: I am a long-time DOME fan girl).

More microbiome research needs to be grounded in microbial ecology and functional work.

Drug limits iron availability --> implications for AMR and virulence.

The Parkinson's drug entacapone disrupts gut microbiome homeostasis via iron sequestration https://www.biorxiv.org/content/10.1101/2023.11.12.566429v1

#microbiome #metabolism #AMR #virulence

Hamied Foundation UK-India AMR Visiting Fellowship scheme open for applications. Excellent initiative.Supports travel and subsistence costs...

Hamied Foundation UK-India AMR Visiting Fellowship scheme open for applications. Excellent initiative.

Supports travel and subsistence costs of UK researchers wishing to visit India, or researchers in India wishing to visit the UK, to develop long-term collaborations in AMR research.

https://acmedsci.ac.uk/grants-and-schemes/grant-schemes/amr-professorships

#microbiology #AMR #collaboration #funding

Importance of Mohamed's work in an Egyptian clinical context.- 31 P. aeruginosa isolates recovered from CAUTIs in an Egyptian hospital...

Importance of Mohamed's work in an Egyptian clinical context.

- 31 P. aeruginosa isolates recovered from CAUTIs in an Egyptian hospital over a 3-month period.
- First detailed genomic data for this pathogen in Egypt.
- Even with this small no. of isolates, genetically diverse isolates, novel resistance determinants and high-risk clones in this clinical setting.
- First report of a pBT2436-like megaplasmid in a clinical P. aeruginosa isolate in the MENA region.

Very pleased to see this out. Delighted for Mohamed, who did a huge amount of phenotypic/genotypic work in the first year of his PhD, as...

Very pleased to see this out. Delighted for Mohamed, who did a huge amount of phenotypic/genotypic work in the first year of his PhD, as well as starting to develop his bioinformatics/data science skills.

*Very proud supervisor*

Phenotypic and genomic characterization of Pseudomonas aeruginosa isolates recovered from catheter-associated urinary tract infections in an Egyptian hospital https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.001125

#microbiology #pseudomonas #AMR #biofilms

Fully funded BBSRC DTP PhD studentship with me and David Negus at Nottingham Trent University, along with Ellis O'Neill at the...

Fully funded BBSRC DTP PhD studentship with me and David Negus at Nottingham Trent University, along with Ellis O'Neill at the University of Nottingham.

oxyMiner: exploiting genomic and metabolomic data to identify secondary metabolites of the Klebsiella oxytoca complex

Open to UK and international students. Details of how to apply to the scheme at https://www.nottingham.ac.uk/bbdtp/

#microbiology #secondarymetabolites #metabolomics

Looking forward to presenting our (@SimonMcArthur) work on methylphenols and the gut-brain axis at the 4th International World of Microbiome...

Looking forward to presenting our (@SimonMcArthur) work on methylphenols and the gut-brain axis at the 4th International World of Microbiome Conference, today in Sofia.

TL;DR - p-cresol glucuronide protective against LPS; p-cresol sulfate very bad if you've got chronic kidney disease.

pCG - https://pubmed.ncbi.nlm.nih.gov/35596559/
pCS - https://www.biorxiv.org/content/10.1101/2022.11.12.516113v1

#gutbrainaxis #microbiome #metabolites

If you are a member of ESCMID and working on AMR, there are opportunities to join their newly formed ESCMID AMR Action Committee. Call opens...

If you are a member of ESCMID and working on AMR, there are opportunities to join their newly formed ESCMID AMR Action Committee. Call opens today and positions are subject to 3-year terms. See https://www.escmid.org/membership-organisation/about-escmid/organisation/subcommittees for details.

Excellent opportunity for Midlands-based individuals from non-traditional academic backgrounds to undertake a PhD on antimicrobial...

Excellent opportunity for Midlands-based individuals from non-traditional academic backgrounds to undertake a PhD on antimicrobial resistance with Dr Jody Winter at Nottingham Trent University.

To paddle or not to paddle? Examining microbial contamination and risk to communities in Nottingham’s rivers https://ufncollaboratory.ac.uk/to-paddle-or-not-to-paddle-whats-in-our-river/ #Microbiology #AMR #environment

Wouldn't normally put up a petition, but this one's important. Survival rates for pancreatic cancer are appalling, and it remains...

Wouldn't normally put up a petition, but this one's important. Survival rates for pancreatic cancer are appalling, and it remains one of the least-studied diseases.

Don’t write off people with pancreatic cancer https://www.pancreaticcancer.org.uk/dont-write-me-off/?utm_campaign=1505134_IC_NFA_DWMO-Launch&utm_medium=email&utm_source=PCUK_DotDigital&dm_i=6OGV,W9DA,5L5S6S,3YYX6,1

Two PhD positions available with Dr Varsha Singh at University of Dundee, working to understand the mechanisms contributing to olfaction....

Two PhD positions available with Dr Varsha Singh at University of Dundee, working to understand the mechanisms contributing to olfaction. #microbiology #metabolomics #metabolites

https://www.dundee.ac.uk/phds/projects/nose-knows-understanding-coupling-olfactory-receptors-g-alpha-proteins-using

https://www.dundee.ac.uk/phds/projects/mechanistic-bases-gain-olfaction-capacity-animals

Crick Africa Network Career Acceleration...

Crick Africa Network Career Acceleration Fellowship

https://www.nature.com/naturecareers/job/12806320/crick-africa-network-career-acceleration-fellowship

"...for ambitious early-career African scientists who can demonstrate strong scientific and leadership potential, a keen interest in translational science, and a commitment to establishing their own research groups and continuing their careers on the African continent."

This is an awesome opportunity!

PhD available with me at NTU. Metabolomics and cell-line work (... maybe some microbiota ...). Open to UK and international...

PhD available with me at NTU. Metabolomics and cell-line work (... maybe some microbiota ...). Open to UK and international students.

Host–microbiota interactions in pancreatic cancer: determining whether they exist, and their influence on disease https://www.ntu.ac.uk/study-and-courses/postgraduate/phd/phd-opportunities/studentships/school-of-science-and-technology-studentships/hostmicrobiota-interactions-in-pancreatic-cancer-determining-whether-they-exist,-and-their-influence-on-disease

Please share.

#microbiome #metabolome #hostmicrobiotainteractions

Microbial dietary protein metabolism regulates GLP‐1 mediated intestinal transit...

Microbial dietary protein metabolism regulates GLP‐1 mediated intestinal transit https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202300982R

#inmice #microbiome

Beyond butyrate: microbial fiber metabolism supporting colonic epithelial homeostasis...

Beyond butyrate: microbial fiber metabolism supporting colonic epithelial homeostasis https://www.sciencedirect.com/science/article/pii/S0966842X23002263?via%3Dihub

#microbiome #metabolites

Potentially useful GPCR tool (but not sure about AD side of things).Comprehensive characterization of multi-omic landscapes between...

Potentially useful GPCR tool (but not sure about AD side of things).

Comprehensive characterization of multi-omic landscapes between gut-microbiota metabolites and the G-protein-coupled receptors in Alzheimer’s disease https://www.biorxiv.org/content/10.1101/2022.09.20.508759v1.full

#microbiome #metabolites

Great day at the European Association for the Study of the Liver's Basic School of Hepatology: Microbiome in Chronic Liver Disease. I...

Great day at the European Association for the Study of the Liver's Basic School of Hepatology: Microbiome in Chronic Liver Disease. I particularly enjoyed Bernd Schnabl's talk on alcohol-related liver disease. Some really cool mycobiome/animal work to show Th17 accumulation in liver tissue.

Anyone know if it's common for two plasmids within the same K. pneumoniae strain to both encode rmpA (regulator of mucoid phenotype)?...

Anyone know if it's common for two plasmids within the same K. pneumoniae strain to both encode rmpA (regulator of mucoid phenotype)? #Klebsiella #plasmids

Deligthed to see this work out, from Petros Andrikopoulos, demonstrating the TMAO-cardiometabolomic health story is complicated. #Microbiome...

Deligthed to see this work out, from Petros Andrikopoulos, demonstrating the TMAO-cardiometabolomic health story is complicated. #Microbiome #TMAO #cardiometabolism

Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide https://www.nature.com/articles/s41467-023-39824-4

A physiologically-based model of bile acid metabolism in mice ...

A physiologically-based model of bile acid metabolism in mice https://www.cell.com/iscience/pdf/S2589-0042(23)01999-5.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004223019995%3Fshowall%3Dtrue #microbiome #metabolites #bileacids

Didn't realize until today: ISAPP consensus statement on postbiotics does not include metabolites...

Didn't realize until today: ISAPP consensus statement on postbiotics does not include metabolites alone.

www.ncbi.nlm.nih.gov/pmc/articles...

Postbiotics are preparations “of inanimate microorganisms and/or their components that confers a health benefit on the host”.

These constitute “deliberately inactivated microbial cells with or without metabolites or cell components that contribute to demonstrated health benefits”, and the microbial cells do not have to come from recognized probiotics.