Thank you to the authors @massgeneralnews for your work, and we look forward to following more of your work in the future!
cc: @aliyousefi
❔3️⃣: There is discussion about why stimulation decreased encoding but enhanced task performance: stimulation reduced ‘excess’ control. We’d be curious to see this stim. setup done using a task-switching paradigm, as it may be that stimulation is improving cognitive flexibility.
2.10.2023 21:17❔3️⃣: There is discussion about why stimulation decreased encoding but enhanced task performance: stimulation reduced ‘excess’...❔2️⃣: In Figure 4C, why would xconflict increase due to the closed-loop stimulation conditioned on xbase? Shouldn’t xconflict be accounted for in xbase, and thus also be improved?
2.10.2023 21:17❔2️⃣: In Figure 4C, why would xconflict increase due to the closed-loop stimulation conditioned on xbase? Shouldn’t xconflict be......to see the effects on striatum and basal ganglia too, and the interactions between these three regions due to the capsule stimulation.
2.10.2023 21:16...to see the effects on striatum and basal ganglia too, and the interactions between these three regions due to the capsule stimulation.3 Questions We Had:
❔1️⃣: In the introduction, there is discussion about dense white matter tracts running through the internal capsule that connect the pFC, striatum, and basal ganglia. However, they only measured pFC effects in the paper. we’d be really curious...
🤍3️⃣: We like the use the MSIT and introduced multiple sources of conflict. It would be interesting to follow-up with examining graded effects for no conflict, one source of conflict, and both sources of conflict.
2.10.2023 21:16🤍3️⃣: We like the use the MSIT and introduced multiple sources of conflict. It would be interesting to follow-up with examining...🤍2️⃣: We also love the use of a closed-loop system, to measure control and stimulate in real-time and stimulate. It’s particularly great to see it applied to a rather nebulous psychological construct like cognitive control.
2.10.2023 21:15🤍2️⃣: We also love the use of a closed-loop system, to measure control and stimulate in real-time and stimulate. It’s particularly...3 Things We Liked:
🤍1️⃣: We love the motivation and goal of this paper, to try to improve cognitive control directly using stimulation, which is the next step in applied cognitive control
Last week, CNAP graduate student Jim Zhang presented fantastic work by Ishita Basu and colleagues looking at closed-loop modulation of cognitive control. This 🧵 explores our thoughts (🤍 & ❔)
https://www.nature.com/articles/s41551-021-00804-y
Some good news: our R01 has been funded! We will study the interactions between speech production and vWM using intracranial recordings. A big thank you to the whole lab and all of our collaborators.
@DukeBrain @DukeNeurology @gregoryhickok
The Cogan Lab is looking for a research technician to analyze data from invasive human neural recordings acquired during verbal working memory tasks. The candidate will work closely with the PI @gcogan and Neurosurgery Resident Daniel Sexton. Join us!
http://coganlab.org/researchtech23
Thank you as well to all the co-authors for your great work!
25.8.2023 15:52Thank you as well to all the co-authors for your great work!❔3️⃣: How do neuronal populations physically switch between orthogonal representations in low-dimensional subspaces?
25.8.2023 15:50❔3️⃣: How do neuronal populations physically switch between orthogonal representations in low-dimensional subspaces?❔2️⃣:Did the RTs differ between subjects with strong and weak coding partitions on repeat trials? A strong coding partition may make it easier to disentangle information between past and present states, decreasing switch cost, but if past and present states share a lot of information (as during repeat trials), would subjects with a weak coding partition decode these trials faster and thus have a lower RT on repeat trials?
25.8.2023 15:49❔2️⃣:Did the RTs differ between subjects with strong and weak coding partitions on repeat trials? A strong coding partition may make...❔1️⃣: What would happen the switch was between drastically different tasks (e.g. stop/go task vs. flanker task)? Would the PFC then need to use higher-dimensional subspaces to encode all of the task information? What about for more stimuli/per task?
25.8.2023 15:49❔1️⃣: What would happen the switch was between drastically different tasks (e.g. stop/go task vs. flanker task)? Would the PFC then...🤍3️⃣:It’s really interesting that there is a relationship between switch cost and coding partition in a between-subjects design. Perhaps there are factors that lead to one person having a strong/weak coding partition, and also potential dis-/advantages in an educational setting.
25.8.2023 15:48🤍3️⃣:It’s really interesting that there is a relationship between switch cost and coding partition in a between-subjects design....🤍2️⃣:The illustration of the multivariate analysis pipeline made it much more clear and understandable.
25.8.2023 15:48🤍2️⃣:The illustration of the multivariate analysis pipeline made it much more clear and understandable.🤍1️⃣:Teasing apart how a shared prefrontal neuronal population can flexibly encode for multiple states, which may indicate a universal neural mechanism for preventing past information from interfering with present processes. This could also be relevant for short-term and LTM.
25.8.2023 15:47🤍1️⃣:Teasing apart how a shared prefrontal neuronal population can flexibly encode for multiple states, which may indicate a...This week, CNAP PhD student Jim Zhang presented a cool new @PNASNews paper from Jan Weber and colleagues on representing information in different subspaces in the PFC. This 🧵 explores our thoughts (🤍 & ❔)
https://www.pnas.org/doi/10.1073/pnas.2220523120
Thank you to the authors
@etrautmann
@SussilloDavid for your excellent work!