danai - Network

Happy & proud to share our latest work with the #bluespot community, #locuscoeruleus enthusiasts, and anyone else willing to read...

Happy & proud to share our latest work with the #bluespot community, #locuscoeruleus enthusiasts, and anyone else willing to read 😉

https://www.biorxiv.org/content/10.1101/2023.10.16.562534v1

4 years ago, we had the idea that endogenous neuromodulatory systems are in place that control LC activity, thereby promoting adaptive behavioral responses in challenging environments.

We examined the role of Neuropeptide Y, as a possible candidate system for this, and identified a new population of #NPY-expressing neurons, distributed in the pericoerulean space.

We showed that peri-LC NPY cells innervate the region, providing #NPY input onto #noradrenergic neurons of the LC, and strongly inhibiting their activity, via Y1Rs.

Next, we showed that chemogenetic stimulation of NPY cells led to anxiety-relief, via Y1Rs, and conversely, inhibition of NPY neurons triggered an anxiogenic phenotype.

Together, we showed a novel role for NPY-mediated #neuromodulation of the LC in adaptive behaviors.

We re happy to hear your thoughts /ideas /feedback on our data.

Please share/boost. Happy reading 🔵

#preprint #neuroscience #systemsneuro #ephys #stress

3 weeks, 3 submission deadlines 😵☠️1/3 (preprint) ✅Please, wish me luck, send the good vibes, dance naked under the moon, anything...

3 weeks, 3 submission deadlines 😵☠️
1/3 (preprint) ✅

Please, wish me luck, send the good vibes, dance naked under the moon, anything helps..

@academicchatter

Why do we have helicopters roaming on a different planet but can't have tights that can be worn twice before falling apart?

Why do we have helicopters roaming on a different planet but can't have tights that can be worn twice before falling apart?

My trip to Barcelona for #CatecholaminesGRC started on the most fitted way possible, me forgetting my poster tube at the check-in desk...

My trip to Barcelona for #CatecholaminesGRC started on the most fitted way possible, me forgetting my poster tube at the check-in desk 🤦‍♀️

Luckily, I could retrieve it before it was too late, but yeah..i need to stop booking such early flights.

Making my poster for #CatecholaminesGRC and couldnt be happier adding my #mastodon #Neuromatch handle at the bottom!Feeling hopeful for a...

Making my poster for #CatecholaminesGRC and couldnt be happier adding my #mastodon #Neuromatch handle at the bottom!

Feeling hopeful for a growing community in a wayyyy more friendly & honest environment. ❤️🐘

Honest question, would appreciate your input as academics /reviewersData for supplemental figure go the right direction, but aren't near...

Honest question, would appreciate your input as academics /reviewers

Data for supplemental figure go the right direction, but aren't near statistical significance (p=0.2) due to low n numbers.

For a manuscript, would you:

@academicchatter #neuroscience #lifescience

Please boost for better results (oh, the irony)

Add data, mention they support your claim
Add data, mention there is no effect
Do not add data, go back and increase n
Other

Thinking about all the default opinions that somehow became facts, and noone ever remembers the paper that supported the transition, and how...

Thinking about all the default opinions that somehow became facts, and noone ever remembers the paper that supported the transition, and how now, i have to run interference with 5 validation experiments & mild but firm discussion points, which should convince but not annoy the reviewers, to be allowed to just show my data.
#rantoftheday #40yearssincethe80s #SupFig8J #manuscriptinprep

Unsolicited PSA: BUY THE FROTHER!

Unsolicited PSA: BUY THE FROTHER!

DORA is here! If you re interested in learning about (& participating in) fair research evaluation, beyond IF & other arbitrary...

DORA is here!
If you re interested in learning about (& participating in) fair research evaluation, beyond IF & other arbitrary metrics, give them a follow.

@DORAssessment

A fantastic day for #bluespot enthusiasts, with the publication of scRNA seq of the mouse #LC.!!The paper goes deep into neuropeptidergic...

A fantastic day for #bluespot enthusiasts, with the publication of scRNA seq of the mouse #LC.!!

The paper goes deep into neuropeptidergic subpopulations within the noradrenergic system, and using galanin (ephys & Ca2+ imaging), exemplifies the countless possibilities of LC neuromodulation by peptidergic signaling. ❤️❤️

Neuronal diversity of neuropeptide signaling, including galanin, in the mouse locus coeruleus | PNAS
https://www.pnas.org/doi/10.1073/pnas.2222095120

Over at the ex-bird, people were always loud about their accomplishments, aka new papers, grants, promotions etc.. I miss this content here...

Over at the ex-bird, people were always loud about their accomplishments, aka new papers, grants, promotions etc..

I miss this content here in mastodon.
I miss what feels like a valuable source of exciting news/data. But mainly, I miss the opportunity to join in the joy.., to massively celebrate milestones & to acknowledge their deserving nature.

I wonder if this is a feature of the less "showy"/more raw character of the fediverse. Or it's just coincidence in the #neuromatch instance TL.

Either way, would REALLY love to hear what people are proud of lately, and cheer along with them. If you do happen to wanna toot your own horn, I'm listening.

@academicchatter

If you have time for the dying bird, you have time to reply my damn email #subtweet #subtoot

If you have time for the dying bird, you have time to reply my damn email #subtweet #subtoot

Offering to the gods of histology. Wish me luck 🤞

Offering to the gods of histology. Wish me luck 🤞

Fantastic resource for the #bluespot community & noradrenergic research as a whole from the Patriarchi lab, available on...

Fantastic resource for the #bluespot community & noradrenergic research as a whole from the Patriarchi lab, available on Addgene

Sensitive multicolor indicators for monitoring norepinephrine in vivo
https://www.nature.com/articles/s41592-023-01959-z

Dreaming about all the cool fiber photometry experiments that are possible now!! 🔵🔵

TIL despair, trying to iron fitted sheets.

TIL despair, trying to iron fitted sheets.

Can we all agree to once and for all bury "seminal" together with the patriarchy?Pretty please choose one of the many:influential,...

Can we all agree to once and for all bury "seminal" together with the patriarchy?

Pretty please choose one of the many:

influential, formative, groundbreaking, pioneering, original, creative, innovative, imaginative, productive, major, important

#rantoftheday

"..the most important chapter of the book investigates disparities in citation rates. As the authors point out, *ideas cannot change a...

"..the most important chapter of the book investigates disparities in citation rates. As the authors point out, *ideas cannot change a field if people do not pay attention to them*. Men are cited more than women are."

Science’s gender gap: the shocking data that reveal its true extent
https://www.nature.com/articles/d41586-023-02139-x

#WomenInSTEM
#equity

Waiting for the Catecholamines #GRC be like#onemonthtogohttps://www.grc.org/catecholamines-conference/2023/

Waiting for the Catecholamines #GRC be like

#onemonthtogo

https://www.grc.org/catecholamines-conference/2023/

Invaluable resource from @AllenInstitute: ABC, cell atlas based on whole brain spatial transcriptomics...

Invaluable resource from @AllenInstitute: ABC, cell atlas based on whole brain spatial transcriptomics

https://knowledge.brain-map.org/data/LVDBJAW8BI5YSS1QUBG/explore

https://www.biorxiv.org/content/10.1101/2023.03.06.531121v1

#openscience

Excellent review on #sabv in stress & mood disorders, discussing past, present & future of research inclusive of sex similarities...

Excellent review on #sabv in stress & mood disorders, discussing past, present & future of research inclusive of sex similarities & differences.

rdcu.be/dgu7x