I would appreciate suggestions for what #Journal to submit to 🙏. I have no personal grants to pay #PublishingCosts or do supporting lab experiments, so the journal would have to understand my situation and waive the costs 🤷 (15/15)
30.12.2022 15:19I would appreciate suggestions for what #Journal to submit to 🙏. I have no personal grants to pay #PublishingCosts or do supporting lab...Motivation for study: Lack of independence has been a major criticism in my #RejectedStartingGrant application reviews. I have been working on this project mostly as a hobby, but I have also used some time @neuroscience_dk funded by @novonordiskfond via @MartinMlauritz (14/15)
30.12.2022 15:18Motivation for study: Lack of independence has been a major criticism in my #RejectedStartingGrant application reviews. I have been working...If you enjoyed this🧵, please read my @biorxiv_neursci #Preprint: https://tinyurl.com/5yfx5d8p. If you have suggestions on how to improve the #Manuscript, please comment using the comment function in BiorXiv (13/15)
30.12.2022 15:18If you enjoyed this🧵, please read my @biorxiv_neursci #Preprint: https://tinyurl.com/5yfx5d8p. If you have suggestions on how to improve...Conclusion: In the #Brain 🧠, #Microvasculature is not #Innervated like in #PeripheralTissue. #PrecapillarySphincters and/or #FirstOrderCapillaries are central to #NeurovascularCoupling, which may be enhanced by perpendicular alignment of #NeuronalProcesses (12/15)
30.12.2022 15:17Conclusion: In the #Brain 🧠, #Microvasculature is not #Innervated like in #PeripheralTissue. #PrecapillarySphincters and/or...#Human🚶♀️#Brain 🧠 has similar arrangement of #NeuronalProcesses around #Microvasculature. Shown here for a #FirstOrderCapillary and an #AscendingVenule in the #H01release 3D #ElectronMicroscopy 🔬 dataset: https://tinyurl.com/mvvunjax (11/15)
30.12.2022 15:17#Human🚶♀️#Brain 🧠 has similar arrangement of #NeuronalProcesses around #Microvasculature. Shown here for a #FirstOrderCapillary...🐭#Brain #Microvasculature is not #Innervated. But #Parenchymal #NeuronalProcesses arrange perpendicular to #Arteriole direction where #PerivascularSpace exists, while #AscendingVenules do not have this arrangement (10/15)
30.12.2022 15:16🐭#Brain #Microvasculature is not #Innervated. But #Parenchymal #NeuronalProcesses arrange perpendicular to #Arteriole direction where...#Astrocytes are generally depicted as #Parenchymal somas with processes reaching the #bloodvessels. Here, I show that #AstrocyteSoma are part of the #Endfeet around #PenetratingArterioles and #AscendingVenules (9/15)
30.12.2022 15:14#Astrocytes are generally depicted as #Parenchymal somas with processes reaching the #bloodvessels. Here, I show that #AstrocyteSoma are...#Collagen is mainly synthesized by #Fibroblasts, strengthening #Arteriole and #Capillary vessel wall. #Ultrastructure shows #fibripositors where #collagenfibril #tripelhelixes are made and #fibrils that reach across the #PerivascularSpace (8/15)
30.12.2022 15:12#Collagen is mainly synthesized by #Fibroblasts, strengthening #Arteriole and #Capillary vessel wall. #Ultrastructure shows #fibripositors...#MyoendothelialJunctions are 🔗s between #MuralCells and #Endothelia, elsewhere separated by the #BasementMembrane. I show how #Brain #PrecapillarySphincters are 🔥spots for these junctions (yellow dots), like Rhodin showed in 🐇 #PeripheralTissue: https://tinyurl.com/cm8chj56 (7/15)
30.12.2022 15:11#MyoendothelialJunctions are 🔗s between #MuralCells and #Endothelia, elsewhere separated by the #BasementMembrane. I show how #Brain...At the #PrecapillarySphincter and #NeurovascularUnit, I show: #EndothelialCell, #MuralCell, #Fibroblast, #Macrophage, #Astrocyte and #Neuron. Also, structures: #ContractileElement, #MyoendothelialJunction, #PinocyticVesicle, #Collagen, #Elastin, #Glycocalyx (6/15)
30.12.2022 15:10At the #PrecapillarySphincter and #NeurovascularUnit, I show: #EndothelialCell, #MuralCell, #Fibroblast, #Macrophage, #Astrocyte and...Results: In this study of the #MICrONS 🐭👁️-cortex 3D #ElectronMicroscopy dataset, I show how the shape of #Contractile #MuralCells transition from #PenetratingArteriole to #PrecapillarySphincter to #Capillaries. Vascular lumen = blue, mural cells = various colors (5/15)
30.12.2022 15:05Results: In this study of the #MICrONS 🐭👁️-cortex 3D #ElectronMicroscopy dataset, I show how the shape of #Contractile #MuralCells...The function 🧑🔧 of the #PrecapillarySphincter is to control the #BloodFlow to the #Capillaries, securing adequate distribution of blood flow between the upper and lower cortical layers. For more, check these🧵: https://bit.ly/3hUEytP and https://tinyurl.com/4e2w3x9n (4/15)
30.12.2022 15:05The function 🧑🔧 of the #PrecapillarySphincter is to control the #BloodFlow to the #Capillaries, securing adequate distribution of...‼️Importantly, #PrecapillarySphincters exist where a #Capillary branches from a much larger #Arteriole (≈upper cortical layers) but not when there is a more gradual transition (≈lower cortical layers). (3/15)
30.12.2022 15:04‼️Importantly, #PrecapillarySphincters exist where a #Capillary branches from a much larger #Arteriole (≈upper cortical layers) but...Introduction: Precapillary sphincters are indentations of the #capillary lumen at where it branches from an #arteriole. With colleagues I have previously shown their location 🗺️ and function 🧑🔧 (https://tinyurl.com/euasfses). (2/15)
30.12.2022 15:03Introduction: Precapillary sphincters are indentations of the #capillary lumen at where it branches from an #arteriole. With colleagues I...🔥🔥🔥Exciting news! I just published a preprint on the #Ultrastructure of #PrecapillarySphincters and the #NeurovascularUnit. This study is based on the https://www.microns-explorer.org/ dataset by @AllenInstitute. Check 🧵 for more details, including movies of the findings. (1/15)
30.12.2022 14:47🔥🔥🔥Exciting news! I just published a preprint on the #Ultrastructure of #PrecapillarySphincters and the #NeurovascularUnit. This...Christmas vibes in #Tallinn 🇺🇦
28.12.2022 18:36Christmas vibes in #Tallinn 🇺🇦Hi #Mastodon, I really want to use this app more, but I just find much more relevant content on Twitter regarding #neurovascular research. How do I change this, or is this just a part of it to ensure that there is no ecco chamber? Please help!
18.12.2022 18:56Hi #Mastodon, I really want to use this app more, but I just find much more relevant content on Twitter regarding #neurovascular research...."A lot of little assholes making a colony to build a bigger asshole." There is a serious brain drain on #Twitter!
28.11.2022 17:39"A lot of little assholes making a colony to build a bigger asshole." There is a serious brain drain on #Twitter!I know 🌨️ is coming, and there will be no 🛶 before summer ☀️... But now is the time to prepare! I got a double kayak/canoe and I think the second seat will soon be filled in 🚣♀️🏆
25.11.2022 16:45I know 🌨️ is coming, and there will be no 🛶 before summer ☀️... But now is the time to prepare! I got a double kayak/canoe and I...⬆️
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