gunninglabuoft - Network

Thrilled to share our #OpenAccess online resource "An Introduction to Medicinal Chemistry & Molecular Recognition" on...

Thrilled to share our #OpenAccess online resource "An Introduction to Medicinal Chemistry & Molecular Recognition" on @OpenLibraryON! We designed this resource to provide budding medicinal chemists with the knowledge & tools to navigate small molecule drug discovery! #OER
https://ecampusontario.pressbooks.pub/medicinalchemistry/

Check out our preprint on an #AI-powered #ligandability prediction platform for bottom-up analysis of #chemoproteomic data to identify...

Check out our preprint on an #AI-powered #ligandability prediction platform for bottom-up analysis of #chemoproteomic data to identify #covalent binding sites, including cryptic sites, for the discovery of novel drug targets.
#proteomics #MachineLearning
https://chemrxiv.org/engage/chemrxiv/article-details/658de2e266c13817293b8174

Thrilled to share our story on the first rationally designed #covalent #HDAC inhibitor! YSR734 uses an SNAr-reactive electrophile to engage...

Thrilled to share our story on the first rationally designed #covalent #HDAC inhibitor! YSR734 uses an SNAr-reactive electrophile to engage a noncatalytic nitrosylation site cysteine in #HDAC2, showing in vitro activity in AML & #DuchenneMuscularDystrophy!
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01236

#Job alert! We're #hiring a Laboratory Technician at the Centre for Medicinal Chemistry (#CMC) @UTM !Join the forefront of...

#Job alert! We're #hiring a Laboratory Technician at the Centre for Medicinal Chemistry (#CMC) @UTM !

Join the forefront of small-molecule therapeutic discovery as an integral member of our team!

Learn more and apply by Nov 28 here:
https://jobs.utoronto.ca/job/Mississauga-Laboratory-Technician-ON/575922617/
#labtech #researchjobs

The Centre for Medicinal Chemistry (CMC) at @UTM is hiring an Administrative Assistant! For more information or to apply, read the full job...

The Centre for Medicinal Chemistry (CMC) at @UTM is hiring an Administrative Assistant! For more information or to apply, read the full job posting here:
https://jobs.utoronto.ca/job/Mississauga-Administrative-Assistant-ON/575276617/

The mystery of @genentech's monovalent BRD degraders equipped with a propargyl "degradation tail" has been solved by...

The mystery of @genentech's monovalent BRD degraders equipped with a propargyl "degradation tail" has been solved by researchers @abbvie: a #CRISPR screen reveals molecular glue-like recruitment of #DCAF16.
#TargetedProteinDegradation #MonovalentDegraders
https://pubs.acs.org/doi/full/10.1021/acschembio.2c00747

Granted, the test case is—you guessed it—#BRD4. Nevertheless, this could be an exciting new #TPD modality if it is generalizable to...

Granted, the test case is—you guessed it—#BRD4. Nevertheless, this could be an exciting new #TPD modality if it is generalizable to other target proteins, such as those lacking accessible lysines or for which #ubiquitination is slow or inefficient.

And it's wonderful to see that our alumnus Gary Tin and the amazing Georg Winter wrote the News & Views piece on this paper!...

And it's wonderful to see that our alumnus Gary Tin and the amazing Georg Winter wrote the News & Views piece on this paper! #gunningalumni
https://www.nature.com/articles/s41589-022-01217-x

An exciting new paper by researchers at Genentech led by Erin Dueber describes a ligase-agnostic #TargetedProteinDegradation platform based...

An exciting new paper by researchers at Genentech led by Erin Dueber describes a ligase-agnostic #TargetedProteinDegradation platform based on direct 26S proteasome recruitment with macrocyclic PSMD2 ligands! Clever use of the D-enantiomeric macrocycle as an inactive control. These bifunctional ligands deliver target proteins to the 26S proteasome near the AAA+ unfoldase pore, bypassing the requirement for E3 ligase-mediated target ubiquitination prior to degradation!
https://www.nature.com/articles/s41589-022-01218-w

Interesting work by Samy Meroueh @IUMedSchool on the development and characterization of reversible #covalent cyanamide antagonists of...

Interesting work by Samy Meroueh @IUMedSchool on the development and characterization of reversible #covalent cyanamide antagonists of TEAD-YAP1 that engage a conserved cysteine palmitoylation site in #TEAD.
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.2c01189

Feel free to give us a follow here (or on the bird site @gunninglabuoft) to keep up with the latest research and news from our group and to...

Feel free to give us a follow here (or on the bird site @gunninglabuoft) to keep up with the latest research and news from our group and to see posts about cool new papers in #medchem, #chemicalbiology, and #drugdiscovery!

Our recent work has focused on the development of small-molecule inhibitors for #HDAC enzymes as well as the "undruggable"...

Our recent work has focused on the development of small-molecule inhibitors for #HDAC enzymes as well as the "undruggable" transcription factors #STAT3 and #STAT5 as potential treatments for hematological malignancies and other cancers.
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.0c01922
https://www.nature.com/articles/s41467-019-10422-7
https://www.nature.com/articles/s41375-017-0005-9

We're a #medicinalchemistry lab in the Centre for Medicinal Chemistry at the University of Toronto Mississauga. Our lab is a dynamic...

We're a #medicinalchemistry lab in the Centre for Medicinal Chemistry at the University of Toronto Mississauga. Our lab is a dynamic research environment with pharma-quality facilities. Research translation is a central goal of our work, and several companies have sprung out of technologies developed in our lab!
https://utm.utoronto.ca/cmc/

Hello, #Chemiverse! We finally made it to Mastodon and can't wait to reconnect with the #chemistry community! But first, let us...

Hello, #Chemiverse! We finally made it to Mastodon and can't wait to reconnect with the #chemistry community! But first, let us (re)introduce ourselves: