#DNAmethylation can be used to infer chronological age (#epigenetic clock). It is also a counter of how many divisions a cell has undergone and this may explain #DNAmethylation dysregulation in cancer, as suggested here https://www.nature.com/articles/s41467-022-34268-8
15.2.2023 11:44#DNAmethylation can be used to infer chronological age (#epigenetic clock). It is also a counter of how many divisions a cell has undergone...maybe an interesting resource in human #DNAmethylation #biomarkers despite the limitations of bisulfite sequencing https://doi.org/10.1038/s41586-022-05580-6
15.2.2023 10:46maybe an interesting resource in human #DNAmethylation #biomarkers despite the limitations of bisulfite sequencing...we also show how #epigenetic identity of #immune cells may be modified in pathological conditions
6.2.2023 07:03we also show how #epigenetic identity of #immune cells may be modified in pathological conditionsour shiny application shows some of our results: http://20.56.136.251:3838/test.app/
6.2.2023 07:01our shiny application shows some of our results: http://20.56.136.251:3838/test.app/where is the information that makes #immune cells different from each other? #DNAmethylation is part of the answer, as we show in our recent #preprint in
#biorxiv https://www.biorxiv.org/content/10.1101/2023.02.03.527091v1
follow up on the previous link on the failure of #PeerReview https://open.substack.com/pub/experimentalhistory/p/the-dance-of-the-naked-emperors?utm_campaign=post&utm_medium=web
23.1.2023 13:19follow up on the previous link on the failure of #PeerReview..." We’re done, everybody! Champagne all around! Great work, and congratulations. We tried #PeerReview and it didn’t work. " https://open.substack.com/pub/experimentalhistory/p/the-rise-and-fall-of-peer-review?utm_campaign=post&utm_medium=web
23.1.2023 13:17" We’re done, everybody! Champagne all around! Great work, and congratulations. We tried #PeerReview and it didn’t work. "...excellent take on the failure of scientific peer review: https://experimentalhistory.substack.com/p/the-rise-and-fall-of-peer-review?ref=refind
23.1.2023 13:14excellent take on the failure of scientific peer review:...In vitro neurons can play a game... Not my field but how cool is this? https://www.cell.com/neuron/fulltext/S0896-6273(22)00806-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627322008066%3Fshowall%3Dtrue
14.11.2022 11:00In vitro neurons can play a game... Not my field but how cool is this?...Here is my #introduction : science & technology enthusiast, senior academic and consultant in #cancer #genomics, I'll be tooting on my field and hoping to engage in productive discussions. Other keywords in case someone else is interested: #DNAmethylation #singlecell #NGS #epigenetics (whatever that means) #bioinformatics #immunotherapy #preprints #opensource #RBioconductor
13.11.2022 12:15Here is my #introduction : science & technology enthusiast, senior academic and consultant in #cancer #genomics, I'll be tooting on...